Gossypol: a potential trypanocidal agent

Podophyllotoxin: a novel potential natural anticancer agent

Objective: The aim of the present review is to give an overview about the role, biosynthesis, and characteristics of Podophyllotoxin (PTOX) as a potential antitumor agent with particular emphasis on key biosynthesis processes, function of related enzymes and characterization of genes encoding the enzymes. Materials and Methods: Google scholar, PubMed and Scopus were searched for literatures wh...

Quinol derivatives as potential trypanocidal agents

Quinols have been developed as a class of potential anti-cancer compounds. They are thought to act as double Michael acceptors, forming two covalent bonds to their target protein(s). Quinols have also been shown to have activity against the parasite Trypanosoma brucei, the causative organism of human African trypanosomiasis, but they demonstrated little selectivity over mammalian MRC5 cells in ...

Terpenoid Derivatives as Potential Trypanocidal Agents

Chagas disease or American trypanosomiasis is a disease caused by the kinetoplastid protozoan Trypanosoma cruzi. This parasitic disease affects millions of people in Latin America and is still expanding worldwide due to migration phenomena. Chagas is one of the most devastating diseases caused by parasites of the Trypanosomatidae family. Trypanosoma cruzi is transmitted through the bite of tria...

soybean: a potential antipsoriasis agent

Soy Isoflavone Genistein Is a Potential Agent for Metabolic Syndrome Treatment: A Narrative Review

Metabolic syndrome has a high prevalence (about 22.4% in adult individuals) in developed countries. Inflammation due to obesity and fat accumulation is the most important factor in the progression of metabolic syndrome. In cells which have a receptor for insulin hormone, inflammatory mediators target the insulin signaling pathway and cause insulin resistance. Peroxisome proliferator-activated r...